By ULY CLINIC
Helicobacter Pylori Related Peptic Ulcer Disease
Introduction
Diagnostic Features
As of diagnostic criteria of Gastroduodenal Ulcers (PUD) and Gastroesophageal Reflux Disease (GERD) together with evidence of
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Positive stool antigen test OR
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Positive urease breath test OR
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Positive urease test on endoscopic biopsy sample OR
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Identification of the pathogen by histopathology examination
Pharmacological Treatment
Triple therapy is indicated for complete eradication of the organism
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Omeprazole (PO) 20mg twice daily Plus amoxycillin (PO) 1000mg twice daily
AND
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Metronidazole (PO) 400mg twice daily for 10–14 days
OR
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Lansoprazole (PO) 30mg twice daily
AND
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Clarithromycin (PO) 500mg twice
AND
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Tinidazole (PO) 500mg twice daily for 10–14 days
OR
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Any combination of PPI + 2 antibiotics active for H. pylori
Note:
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H.pylori diagnostic tests should be repeated 3 months after 2weeks of triple therapy to confirm eradication.
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Refer to next level of care with adequate expertise and facility for cases refractory to conventional triple therapy or persistent of symptoms or new onset complications
Updated on, 2.11.2020
References
1. STG